Journal: Comprehensive Physiology

Article Title: Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

doi: 10.1002/cph4.70159

Figure Lengend Snippet: Vasorelaxant effects of β‐AR agonists in thoracic aorta from SHRs and wild‐type C57BL6 mice. The graphs illustrate the vasorelaxant responses of female and male aortic rings, with and without endothelium, to β‐AR agonists. Panel (A) shows the effects of the β 1 /β 2 ‐AR agonist isoprenaline and the β 3 ‐AR agonist BRL‐37344 in female and male SHRs. Significant sex differences are observed in SHRs, and these differences are endothelium‐dependent, as removal of the endothelium abolishes the enhanced responses in females. Panel (B) depicts the effects of the same β‐AR agonists in female and male wild‐type mice, where no significant sex differences are detected, and endothelial removal has no measurable effect. Experiments were performed with n = 6 for both SHRs and wild‐type mice. All values are presented as mean ± SD. Panel (A) is created based on data from Al‐Gburi et al. .

Article Snippet: Following pre‐constriction with phenylephrine (PE; 10 −6 M; Sigma‐Aldrich, P6126), cumulative concentration‐response curves were generated using the β1/β2‐AR agonist isoprenaline (10 −11 –10 −6 M; Tocris Bioscience, 1747) or the β3‐AR agonist BRL 37344 sodium salt (10 −9 –10 −4 M; Tocris Bioscience, 0948) according to Al‐Gburi et al. ( ).

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